abstract：:The effects of intranasal pretreatment with antibodies against glutamate on focal penicillin-induced epileptic activity were studied by recording electrocorticogram in non-anesthetized freely moving male Wistar rats. Anticonvulsant effects of intranasal administration of anti-glutamate antibodies (300 μg/kg) 1 h befor...

journal_title：Bulletin of experimental biology and medicine

authors： Kuznetsova LV,Karpova MN,Vetrile LA,Klishina NY

更新日期：2013-09-01 00:00:00

abstract：:An integrative systemic model of pharmacological reaction to a phytopreparation was created as a result of conceptual structurization of facts and formalization of causal relations. The use of the new methodological approach to the choice, primary screening, and profound studies of plants for prospective addition ther...

journal_title：Bulletin of experimental biology and medicine

authors： Mitrofanova IY,Yanitskaya AV,Butenko DV

更新日期：2013-09-01 00:00:00

abstract：:We studied the effect of gold nanospheres coated with components of autologous blood plasma on ADP-induced platelet aggregation. Gold nanoparticles in the chosen concentration range (5-40 μM) and particle size (5-30 nm) with or without coating produced no activating effect on platelet aggregation caused by aggregation...

journal_title：Bulletin of experimental biology and medicine

authors： Aseychev AV,Azizova OA,Beckman EM,Dudnik LB,Sergienko VI

更新日期：2013-09-01 00:00:00

abstract：:The effects of LPS from E. coli on DNA-binding activities of PPARα and PPARγ in the liver and immune system parameters of were studied in hypertensive ISIAH rats and normotensive WAG rats. In ISIAH rats characterized by low basal level of PPARα, PPARγ, and HDL, the response of the peripheral immune system compartment ...

journal_title：Bulletin of experimental biology and medicine

authors： Shurligina AV,Dushkin MI,Melnikova EV,Panteleeva NG,Tenditnik MV,Chrapova MV,Trufakin VA

更新日期：2013-08-01 00:00:00

abstract：:We studied properties of bacterial biofilms during long-term culturing. The biofilms were preserved for more than 90 days under the chosen conditions. At the same time, amounts of matrix and cells underwent periodic changes. The biomass of the biofilms decreased approximately every 7 days and then returned to the prev...

journal_title：Bulletin of experimental biology and medicine

authors： Tetz GV,Artemenko NK,Zaslavskaya NV,Tetz VV

更新日期：2013-08-01 00:00:00

abstract：:Immunocytochemical study has shown that Ki-67 antigen is detected in adenomyosis in both endometrial and myometrial cell populations (in the eutopic and ectopic endometrial glandular epithelium, stromal cells, smooth muscle cells, and vascular endotheliocytes of the endometrium and myometrium), the label index differi...

journal_title：Bulletin of experimental biology and medicine

authors： Nepomnyashchikh LM,Lushnikova EL,Molodykh OP,Pichigina AK

更新日期：2013-08-01 00:00:00

abstract：:We studied the effect of 20 standard L-amino acids on proliferation of the nervous, cardiovascular, urogenital, digestive, and immune system tissues from young and old animals in organotypic cultures. The effect of amino acids on tissue culture proliferation depended on their origin and animal age. ...

journal_title：Bulletin of experimental biology and medicine

authors： Chalisova NI,Kontsevaya NE,Linkova NS,Pronyaeva VE,Chervyakova NA,Umnov RS,Benberin VV,Khavinson VH

更新日期：2013-08-01 00:00:00

abstract：:The dose-dependent effect of intranasal administration of antibodies to glutamate on acute generalized epileptic activity was studied in C57Bl/6 mice. It was shown that pretreatment with antibodies in doses of 100, 300, and 500 μg/kg 1 h before titration with convulsant pentylenetetrazole had anticonvulsant effects. T...

journal_title：Bulletin of experimental biology and medicine

authors： Karpova MN,Kuznetsova LV,Vetrile LA,Klishina NJ

更新日期：2013-07-01 00:00:00

abstract：:We studied the effects of phenazepam (0.075 mg/kg) after pretreatment (5 minutes before) with naloxone (10 mg/kg) on open-field behavior of C57Bl/6 and BALB/c mice. In ex vivo experiments, we studied the effects of naloxone (1 and 10 mg/kg) on receptor binding of [(3)H]-flunitrazepam by membranes of brain fraction (P1...

journal_title：Bulletin of experimental biology and medicine

authors： Seredenin SB,Nadorova AV,Kolik LG,Yarkova MA

更新日期：2013-07-01 00:00:00

abstract：:More than 70% malignant mammary tumors contain steroid hormone receptors; this suggests the possibility of hormone therapy in the majority of patients with breast cancer (BC). The main cause of inefficiency of hormone therapy in BC is hormone resistance (tumor resistance to hormonal cytostatics). Here we discuss the m...

journal_title：Bulletin of experimental biology and medicine

authors： Scherbakov AM,Krasil'nikov MA,Kushlinskii NE

更新日期：2013-07-01 00:00:00

abstract：:The antidepressant, psychostimulant, and nootropic effects of a composition of major and trace elements including KCl, RbNO3, magnesium sulfate, and zinc sulfate were studied on the models of behavioural despair (Porsolt test) and conditioned passive avoidance test. The preparation was found to shorten the immobilizat...

journal_title：Bulletin of experimental biology and medicine

authors： Afanasieva OG,Suslov NI,Shilova IV

更新日期：2013-06-01 00:00:00

abstract：:Human recombinant erythropoietin adsorbed on poly(butyl)cyanoacrylate nanoparticles and administered intraperitoneally in a dose of 0.05 mg/kg exhibited a neuroprotective effect in experimental intracerebral posttraumatic hematomas (hemorrhagic stroke) and reduced animal mortality. Human recombinant erythropoietin, na...

journal_title：Bulletin of experimental biology and medicine

authors： Solev IN,Balabanyan VY,Volchek IA,Elizarova OS,Litvinova SA,Garibova TL,Voronina TA

更新日期：2013-06-01 00:00:00

abstract：:Lipemia modeled by injections of Triton WR-1339 (500 mg/kg) and poloxamer 407 (500 mg/kg) to mice were compared. LP fraction and subfraction compositions were compared by small-angle X-ray scattering on a diffractometer. Both compounds in the same dose caused a sharp increase in serum concentrations of total cholester...

journal_title：Bulletin of experimental biology and medicine

authors： Loginova VM,Tuzikov FV,Tuzikova NA,Korolenko TA

更新日期：2013-06-01 00:00:00

abstract：:We studied the role of ryanodine receptors in the effects of hydrogen sulfide on transmitter release from frog motor nerve ending. Sodium hydrosulfide (300 μM), a donor of hydrogen sulfide, reversibly increased the frequency of miniature endplate current without changes in its amplitude-time parameters. These effects ...

journal_title：Bulletin of experimental biology and medicine

authors： Gerasimova EV,Yakovleva OV,Zefirov AL,Sitdikova GF

更新日期：2013-05-01 00:00:00

abstract：:The appearance of autoantibodies to neuronal proteins (S100, GFAP, MBP, and NGF) in rat serum was analyzed by ELISA on days 5, 10, 17, 25, and 32 after streptozotocin injection. Simultaneously, blood glucose and insulin autoantibodies were assayed. Serum glucose level increased on the next day after streptozotocin inj...

journal_title：Bulletin of experimental biology and medicine

authors： Lotosh NG,Savel'eva EK,Selishcheva AA,Savel'ev SV

更新日期：2013-05-01 00:00:00

abstract：:Spontaneous platelet aggregation was evaluated in patients with acute coronary syndrome on days 1, 3-5, and 8-12 of the disease. On day 1, aggregation was analyzed after aspirin, but before clopidogrel administration; during other periods after both antiaggregants. The mean levels of spontaneous aggregation after anti...

journal_title：Bulletin of experimental biology and medicine

authors： Mazurov AV,Khaspekova SG,Yakushkin VV,Khachikyan MV,Zyuryaev IT,Ruda MY

更新日期：2013-05-01 00:00:00

abstract：:We studied multipotent mesenchymal stromal cells isolated from the bone marrow of young (1 month) and old (>12 months) rats. The cell cultures derived from old rats were characterized by lower cell yield in the primary culture, lower number of doublings, and reduced colony-forming capacity of precursor cells. ...

journal_title：Bulletin of experimental biology and medicine

authors： Valyushina MP,Buravkova LB

更新日期：2013-05-01 00:00:00

abstract：:Quantitative assay of nitric oxide (NO) and iron (Fe) was carried out by the electron paramagnetic resonance (EPR) method in epidermal derivative (hair) of 45 liquidators of the Chernobyl accident, 30 employees of radiological institutions having contact with radiation, and 50 students of Vladimir State University, mo...

journal_title：Bulletin of experimental biology and medicine

authors： Petukhov VI,Baumane LK,Reste ED,Zvagule TY,Romanova MA,Shushkevich NI,Sushkova LT,Skavronsky SV,Shchukov AN

更新日期：2013-04-01 00:00:00

abstract：:Applications of cold and warm activated cellular immunity and orientation and exploratory behavior in mice. Application of cold increased the number of turns to the left in the open field, muscle force, and activity of the food instinct, and caused an increase in the total count of peripheral blood leukocytes. Warm ap...

journal_title：Bulletin of experimental biology and medicine

authors： Kalyonova LF,Novikova MA

更新日期：2013-04-01 00:00:00

abstract：:Incomplete varying obstruction of the urinary tract was reproduced by injecting artificial stomatological material into the rat bladder. Inflammatory changes and nephrosclerosis were detected in the renal tissue on days 14 and 21 of the experiment. Urinary concentration of total protein and activity of γ-glutamylamino...

journal_title：Bulletin of experimental biology and medicine

authors： Sosnin DA,Novochadov VV,Ostrovsky OV

更新日期：2013-04-01 00:00:00

abstract：:The effect of streptozotocin-induced diabetes mellitus on some parameters of energy metabolism and functional status of cell membranes was studied in experiments on rats. It was found that the development of diabetes mellitus is associated with dramatic changes in the metabolism of blood cells and kidney tissue: inhib...

journal_title：Bulletin of experimental biology and medicine

authors： Mikaelian NP,Gurina AE,Terent'ev AA

更新日期：2013-03-01 00:00:00

abstract：:Therapy of rats with CCl4 hepatitis with Stellaria media L. water-soluble polysaccharide fraction in a dose of 100 mg/kg reduces serum activities of transaminases (ALT and AST), alkaline phosphatase, bilirubin, and the thymol test values. In the liver, the density of inflammatory infiltration of the organ parenchyma, ...

journal_title：Bulletin of experimental biology and medicine

authors： Gorina YV,Saprykina EV,Gereng EA,Perevozchikova TV,Krasnov EA,Ivanova EV,Fait EA,Baranova OV

更新日期：2013-03-01 00:00:00

abstract：:Experiments on the model of thermal skin burn in rats showed that the use of wound dressing based on collagen-chitosan complex Kollakhit-Bol in local treatment of grade IIIb skin burns increased healing rate by accelerating the formation of granulation and fibrous connective tissues and reducing crust thickness in com...

journal_title：Bulletin of experimental biology and medicine

authors： Kirichenko AK,Bolshakov IN,Ali-Riza AE,Vlasov AA

更新日期：2013-03-01 00:00:00

abstract：:Experiments on the model of an aggressive-conflict situation were designed to study the effect of emotional stress on biogenic amine content in the sensorimotor cortex of the right cerebral hemisphere in behaviorally active and passive rats with experimental hemorrhage in the left caudate nucleus of the brain. Prior e...

journal_title：Bulletin of experimental biology and medicine

authors： Pertsov SS,Ivannikova NO,Krylin VV

更新日期：2013-02-01 00:00:00

abstract：:The epileptogenic effects of applications of NMDA and kainic acid solutions to the frontal cortex were attenuated in rats receiving ketogenic diet (80% lipids, 3.3% carbohydrates, and 16.7% proteins) during 4 weeks. Spike latency increased, the power of focal epileptic activity decreased, and focus lifetime was shorte...

journal_title：Bulletin of experimental biology and medicine

authors： Kresyun VI,Polyasny VA,Godovan VV,Godlevsky LS

更新日期：2013-02-01 00:00:00

abstract：:We evaluated normal blood glucose levels in two species of monkeys, namely rhesus monkeys (Macaca mulatta) and cynomolgus macaques (Macaca fascicularis) kept in the Breeding Center of the Institute of Medical Primatology. The animals were either under moderate stress due to catching or after recovery of defensive and ...

journal_title：Bulletin of experimental biology and medicine

authors： Lapin BA,Gvozdik TE,Klots IN

更新日期：2013-02-01 00:00:00

abstract：:Using rat model of spinal cord contusion injury at TVIII, we compared the effectiveness of immediate single transplantation of human mononuclear umbilical cord blood cells transfected with pBud-VEGF-FGF2 plasmid and immediate direct injection of the same plasmid into the lesion area. The results suggest that the deliv...

journal_title：Bulletin of experimental biology and medicine

authors： Shaymardanova GF,Mukhamedshina YO,Salafutdinov II,Rizvanov AA,Chelyshev YA

更新日期：2013-02-01 00:00:00

abstract：:Calmodulin inhibitor W-7 did not cause changes in the quantal content of postsynaptic end-plate potentials (EPP) in newly formed synapses, but prevented facilitation of acetylcholine secretion induced by L-type Ca(2+)channels blocker nitrendipine. CaMKII inhibitor KN-62 produced similar effect and suppressed the incre...

journal_title：Bulletin of experimental biology and medicine

authors： Bogatcheva PO,Balezina OP

更新日期：2013-01-01 00:00:00

abstract：:We studied the expression of genes encoding angiotensinogen (Agt), renin (Ren), angiotensin-converting enzyme (ACE), and type 1 angiotensin receptor (AT1A) in the hypothalamus and medulla oblongata of hypertensive ISIAH rats and normotensive WAG rats. The amount of Agt mRNA in the hypothalamus of young ISIAH rats was ...

journal_title：Bulletin of experimental biology and medicine

authors： Klimov LO,Fedoseeva LA,Ryazanova MA,Dymshits GM,Markel AL

更新日期：2013-01-01 00:00:00

abstract：:Data are presented on chemical study of flavonoid glycosides in some botanical subjects using matrix-assisted laser desorption ionization, compared to HPLC. The method of matrix-assisted laser desorption ionization (MALDI) allows characterizing the composition of anthocyanin and flavonoid mixture without preliminary s...

journal_title：Bulletin of experimental biology and medicine

authors： Novikov OO,Pisarev DI,Zhilyakova ET,Novikova MY,Pisareva NA,Voronkova OS,Bezmenova MD

更新日期：2013-01-01 00:00:00

abstract：:We used tests for evaluation of latent period, duration, and accuracy of eyes, head, or hand movements and their coordinated movements. Comparative analysis of these parameters was performed in healthy subjects and in patients with early stages of Parkinson's disease. The pathology data significantly (p<0.05) differed...

journal_title：Bulletin of experimental biology and medicine

authors： Baziyan BKh

更新日期：2012-12-01 00:00:00

abstract：:The study compared the effects of phytococktail Bioritm-E (a multicomponent phytoadaptogen) and experimental preparation Skvaakan from the liver of Black Sea spurdog on systemic homeostasis, microcirculation, and blood lipid profile in 15 days of their daily administration. Skvaakan enhanced the platelet activity prod...

journal_title：Bulletin of experimental biology and medicine

authors： Datieva FS,Khetagurova LG

更新日期：2012-12-01 00:00:00

abstract：:Penetration of titanium dioxide nanoparticles into enterocytes after their administration into isolated loop of rat small intestine was shown in vivo by transmission electron microscopy. Using electron diffraction, titanium dioxide nanoparticles were identified in the apical regions of the cells under plasma membranes...

journal_title：Bulletin of experimental biology and medicine

authors： Onishchenko GE,Erokhina MV,Abramchuk SS,Shaitan KV,Raspopov RV,Smirnova VV,Vasilevskaya LS,Gmoshinski IV,Kirpichnikov MP,Tutelyan VA

更新日期：2012-12-01 00:00:00

abstract：:Manifestations of hunger and satiation in myoelectric activity patterns in different portions of the stomach were studied in chronic experiments. The state of hunger manifested in the structure of temporal organization of slow electric activity of muscles in the stomach body and antrum in the form of bimodal distribut...

journal_title：Bulletin of experimental biology and medicine

authors： Kromin AA,Zenina OY

更新日期：2012-11-01 00:00:00

abstract：:Multiple dilutions of the original substance release its peculiar activity referred to as "release-activity". Although this activity originates from the initial substance, it does not depend on its negligible concentration in extreme dilutions. Thus, the terms "dose", "ultralow dose", and "homeopathic dose", do not co...

journal_title：Bulletin of experimental biology and medicine

authors： Epstein OI

更新日期：2012-11-01 00:00:00

abstract：:Enlargement of the brain weight was attained in rats by reducing the number of neonates in the litter. The brain of 14- and 30-day-old animals was examined (controls: intact animals from litters of average numbers). Difference between the brain weight at 14 and 30 days was about 200 mg. The parameter in the experiment...

journal_title：Bulletin of experimental biology and medicine

authors： Ryzhavskii BY,Litvintseva EM

更新日期：2012-11-01 00:00:00

abstract：:The study was undertaken to determine the mechanism of carnosine effect on cell proliferation. We studied the effect of carnosine and its derivatives on cell cycle progression in cultured rat pheochromocytoma cells (PC-12). It was found that 48-h incubation of PC-12 cells with carnosine in concentrations of 10-50 mM l...

journal_title：Bulletin of experimental biology and medicine

authors： Rybakova YS,Boldyrev AA

更新日期：2012-11-01 00:00:00

abstract：:We studied the specific features of ultrasonic vocalization of Wistar rats in various motivational and emotional states. No significant changes were found in ultrasonic vocalization of rats during experimental food motivation and after the satisfaction of food requirements. The state of thirst and satisfaction of wate...

journal_title：Bulletin of experimental biology and medicine

authors： Pertsov SS,Koplik EV,Karkishchenko NN,Sudakov KV

更新日期：2012-10-01 00:00:00

abstract：:Regeneratory activities of Baikal aconite alkaloids were studied on the excision skin wound model. Manifest wound healing effects of songorine, napelline, and hypaconitine were detected. The therapeutic efficiency was based on activation of residual mesenchymal progenitor elements. The development of this phenomenon w...

journal_title：Bulletin of experimental biology and medicine

authors： Zyuz'kov GN,Krapivin AV,Nesterova YV,Povetieva TN,Zhdanov VV,Suslov NI,Fomina TI,Udut EV,Miroshnichenko LA,Simanina EV,Semenov AA,Kravtsova SS,Dygai AM

更新日期：2012-10-01 00:00:00

abstract：:The study included 52 patients at a high risk of thromboembolic complications, with permanent atrial fibrillation. All patients were treated with acenocoumarol for 6 months and the incidence of hemorrhages was evaluated in all of them. All patients were genotyped by CYP2C9 and VKORC1. The presence of CYP2C9*2 and CYP2...

journal_title：Bulletin of experimental biology and medicine

authors： Sychev DV,Ignatyev IV,Emelyanov NV,Milovanova VV,Kossovskaya AV,Kukes IV,Tashenova AI,Kukes VG

更新日期：2012-10-01 00:00:00